Nolvadex and tamoxifen are among the two most popular drug medications used for breast cancer treatment nowadays. However, these two drugs have their own limitations and may not be suitable or efficient in all kinds of breast cancer cases. Read on this article for more information about these two medications and the kinds of cancer they are most effective in treating.
Nolvadex belongs to synthetic estrogens category, a kind of female sex hormone estrogen which mimics and behaves similarly to human Nolvadex estrogen. Nolvadex is mainly intended for oral use and has to be taken according to prescribed directions. This form of estrogen is acting just like an estrogen receptor antagonist and it basically prevents estrogen effect on tumors caused by this hormone by completely blocking its action. Tamoxifen Citrate likewise offers another good benefit to women bodybuilders because it can help increase the levels of testosterone which the body produces by stimulating the pituitary gland’s production of hormone in the blood.
In the past, nolvadex and tamoxifen citrine has been associated with some serious undesirable adverse effects including blood clots, hot flashes, depression, sexual dysfunction, urinary retention, headaches, chest pain, joint pains, and facial swelling. Such adverse events were reported even though there was no clear evidence of the drug’s efficacy or toxicity. One of the drugs, nolvadex was also found to be linked to an increased risk of developing breast cancer among postmenopausal women. The estrogen-like properties of the said drug therefore makes it more dangerous than beneficial. Recently, a large clinical trial which aims to evaluate the effects of nolvadex plus estrogen-like effects of gugulipid plus nolvadex revealed that there is a marked reduction in the incidence of osteoporosis and breast cancer among women using these medications.
But then, is it really safe? The risks that are commonly associated with estrogen therapy are related to both the nolvadex and its active ingredient, nsabp b-14. The placebo effects are considered to be very mild and non-existent in this case. The main reason why this adverse effect occurred is because the doses of the active ingredient used in the placebo pills were much lower than those used in the study. In addition, the administration of the two medications involved a number of important factors such as oral habits, skin sensitivity, medications allergies, and other illnesses that may have affected the response of the subjects.
But then, is there really something wrong with Nolvadex? There are a number of possible risks among women who take this medication for the treatment of perimenopause and other symptoms of menopause. Among these are an increased risk of osteoporosis and breast cancer. In addition, the placebo effects among women can also lead to an increase in the severity of hot flashes. This is because the use of a treatment as usual can sometimes cause the body to respond to it as if it was really needed, thus increasing the chances of experiencing symptoms of menopause and osteoporosis.
However, the results of the study are still inconclusive. In fact, the experts do not yet claim that Nolvadex has a definite benefit on the treatment of perimenopause and other symptoms of menopause. However, they have admitted that these results can help them in determining the safety of the treatment among women with the atypical hyperplasia or genetically determined increase in estrogen levels. They also said that further studies must be conducted to fully understand the effects of Nolvadex on the risk factors of breast cancer.